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Lymph node metastasis in gastric cardiac adenocarcinoma in male patients
Gang Ren1, Ying-Wei Chen, Rong Cai
1Gang Ren, Department of Radiology, Xin Hua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China.
Insights
Tumor differentiation and pathological tumor depth are key risk factors for lymph node metastases in male gastric cardiac adenocarcinoma patients. These factors are crucial for surgical decision-making in gastric cancer treatment.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Gastric cardiac adenocarcinoma is a significant health concern.
- Understanding risk factors for lymph node metastasis is crucial for effective treatment planning.
Purpose of the Study:
- To identify clinicopathological features and risk factors for lymph node metastases in male patients with gastric cardiac adenocarcinoma.
Main Methods:
- Retrospective review of 146 patients undergoing curative gastrectomy with lymphadenectomy.
- Analysis based on Japanese gastric cancer treatment guidelines.
- Univariate and multivariate analyses of clinicopathological features and lymph node metastasis.
Main Results:
- Lymph node metastasis rate was 72.1% in male patients.
- Tumor differentiation and pathological tumor depth identified as independent risk factors.
- No significant differences in features or metastasis rates between male and female patients.
Conclusions:
- Tumor differentiation and depth are critical risk factors for lymph node metastasis in male gastric cardiac adenocarcinoma.
- These factors should guide surgical strategy for improved patient outcomes.
Aim:
To reveal the clinicopathological features and risk factors for lymph node metastases in gastric cardiac adenocarcinoma of male patients.
Methods:
We retrospective reviewed a total of 146 male and female patients with gastric cardiac adenocarcinoma who had undergone curative gastrectomy with lymphadenectomy in the Department of Surgery, Xin Hua Hospital and Rui Jin Hospital of Shanghai Jiaotong University Medical School between November 2001 and May 2012. Both the surgical procedure and extent of lymph node dissection were based on the recommendations of Japanese gastric cancer treatment guidelines. Univariate and multivariate analyses of lymph node metastases and the clinicopathological features were undertaken.
Results:
The rate of lymph node metastases in male patients with gastric cardiac adenocarcinoma was 72.1%. Univariate analysis showed an obvious correlation between lymph node metastases and tumor size, gross appearance, differentiation, pathological tumor depth, and lymphatic invasion in male patients. Multivariate logistic regression analysis revealed that tumor differentiation and pathological tumor depth were the independent risk factors for lymph node metastases in male patients. There was an obvious relationship between lymph node metastases and tumor size, gross appearance, differentiation, pathological tumor depth, lymphatic invasion at pN1 and pN2, and nerve invasion at pN3 in male patients. There were no significant differences in clinicopathological features or lymph node metastases between female and male patients.
Conclusion:
Tumor differentiation and tumor depth were risk factors for lymph node metastases in male patients with gastric cardiac adenocarcinoma and should be considered when choosing surgery.
