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Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength.

Connor Randall, Daniel Bridges, Roberto Guerri

    Journal of Medical Devices
    |October 12, 2013
    PubMed
    Summary

    A new handheld instrument measures bone strength by assessing indentation resistance. This device shows promise for in-vivo bone material strength assessment in humans and animals.

    Keywords:
    bonebone fracturebone material propertiesbone mechanical properties

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    Area of Science:

    • Biomedical Engineering
    • Orthopedics
    • Materials Science

    Background:

    • Assessing bone quality is crucial for diagnosing and managing skeletal diseases.
    • Previous methods for measuring bone material properties often require invasive procedures or are limited to ex-vivo analysis.
    • A non-invasive, handheld device for in-vivo bone assessment could revolutionize orthopedic diagnostics.

    Purpose of the Study:

    • To introduce and evaluate a novel handheld Reference Point Indentation (RPI) instrument for measuring bone material strength in living subjects.
    • To demonstrate the instrument's capability in laboratory settings, including through soft tissue.
    • To present preliminary results from human and animal clinical trials.

    Main Methods:

    • Development of a handheld Reference Point Indentation (RPI) instrument.
    • Testing the RPI instrument on bone samples in laboratory conditions, with and without overlying soft tissue.
    • Conducting clinical trials involving human patients and horses to assess in-vivo bone material strength.

    Main Results:

    • The RPI instrument provides consistent measurements of bone material strength, even when testing through soft tissues like skin and periosteum.
    • Reproducible results were obtained in measurements on horses, both through tissue and on bare bone.
    • Human clinical trials yielded reasonable and consistent bone material strength values, indicating potential for in-vivo application.

    Conclusions:

    • The handheld RPI instrument, Osteoprobe®, shows capability for measuring bone material strength in vivo.
    • The device's ability to test through soft tissue represents a significant advancement over previous RPI instruments.
    • Further large-scale studies are necessary to establish the clinical efficacy of the Osteoprobe® for medical diagnosis.