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Risk of cerebral palsy in term-born singletons according to growth status at birth

Magnus Odin Dahlseng1, Guro L Andersen, Lorentz M Irgens

  • 1Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Developmental Medicine and Child Neurology
|October 15, 2013
PubMed

Insights

Birth size measurements are linked to cerebral palsy (CP) risk. Both small and large infants, particularly those with abnormal length or head circumference, face increased CP incidence, suggesting varied causes.

Area of Science:

  • Neonatal research
  • Pediatric neurology
  • Public health

Background:

  • Cerebral palsy (CP) risk is elevated in infants with low or high birthweight.
  • Limited research exists on the association between other anthropometric measurements at birth and CP risk.

Purpose of the Study:

  • To investigate the relationship between various birth size measurements and the incidence of cerebral palsy in term-born singletons.

Main Methods:

  • Utilized data from the Medical Birth Registry of Norway (1996-2006) for term-born singletons.
  • Calculated z-scores for weight, length, head circumference, and ponderal index.
  • Compared measurements of 398 infants with CP to 490,022 typically developing infants.

Main Results:

  • Low birthweight, low/high length z-scores, and low/high head circumference z-scores were associated with increased CP risk, especially spastic bilateral CP.
  • Spastic unilateral CP was linked to low z-scores for length and head circumference.
  • Large infants with low ponderal index had higher risks of spastic quadriplegic and dyskinetic CP.

Conclusions:

  • Findings suggest most CP subtypes stem from poor intrauterine growth (antenatal factors).
  • CP in large newborns may be more associated with intrapartum complications.
Abstract

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