Related Experiment Video
Updated: May 7, 2026
23:53
Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
7.5K
How pain arises in Parkinson's disease?
G Defazio1, M Tinazzi, A Berardelli
1Department of Basic Medical Sciences, Neurosciences and Sense Organs, 'Aldo Moro' University of Bari, Bari, Italy.
European Journal of Neurology
|October 15, 2013
Summary
Pain in Parkinson's disease (PD) stems from altered central pain processing in the brain, affecting both PD patients with and without pain. These changes offer potential targets for effective pain management strategies.
Area of Science:
- Neuroscience
- Neurology
- Pain Research
Background:
- Parkinson's disease (PD) is increasingly recognized for associated pain.
- Pain in PD presents with diverse qualities and body distributions.
- Understanding pain mechanisms in PD is crucial for treatment.
Purpose of the Study:
- To review evidence on pain in Parkinson's disease.
- To clarify the relationship between pain types and PD.
- To propose potential treatment strategies for PD pain.
Main Methods:
- Review of psychophysical data in PD patients.
- Analysis of neurophysiological studies in PD patients.
- Examination of imaging data in PD patients with and without pain.
Main Results:
- Abnormal central nociceptive processing is evident in PD.
- Impairments in lateral and medial pain pathways are suggested.
- Altered pain processing underlies various pain types, even in patients without overt pain.
Conclusions:
- Central pain processing changes are fundamental to PD pain.
- These alterations may predispose PD patients to spontaneous pain.
- Interactions with factors like rigidity and dystonia shape clinical pain presentation, offering treatment targets.
Related Concept Videos
01:24Parkinson Disease ll: Pathophysiology
34
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
34
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:24Parkinson Disease l: Introduction
28
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
28
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:37Neural Regulation
34.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
34.8K
01:23Degenerative Disc Disease ll: Pathophysiology
36
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
36