Related Experiment Video
Updated: May 7, 2026
Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
Published on: April 28, 2026
Efficiency of endocytoscopy in differentiating types of serrated polyps
Makoto Kutsukawa1, Shin-Ei Kudo1, Nobunao Ikehara1
1Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Background:
Accurate endoscopic criteria are needed to differentiate serrated polyps, including hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA), because some are precursors of colorectal cancers.
Objective:
To determine the endocytoscopic features of each type of serrated polyp, especially the shapes of lumens and nuclei.
Design:
Retrospective study.
Setting:
Single, tertiary-care referral center.
Patients:
Patients who underwent removal of serrated polyps from May 2005 to December 2012.
Intervention:
Endocytoscopy was performed. Endocytoscopic images were evaluated by assessing the shapes of the lumens and nuclei of the target lesions.
Main Outcome Measurements:
The significant endocytoscopic features in differentiating among types of serrated polyps.
Results:
Of the 58 eligible lesions, 27 were classified as HP, 12 as SSA/P, and 19 as TSA. Most HPs (77.8%) had star-like lumens, and most SSA/Ps (83.3%) had oval lumens. The lumens of TSAs were serrated (31.6%) or villous (68.4%), with both shapes seen only in TSAs. Most HPs (92.6%) and SSA/Ps (75.0%) had small, round nuclei, and all TSAs had fusiform nuclei. Features significantly differentiating TSAs from HPs and SSA/Ps were the presence of fusiform nuclei (P < .001) and villous (P < .001) and serrated (P = .002) lumens. The presence of oval lumens was significantly characteristic of SSA/Ps (P < .001), and the presence of star-like lumens was significantly characteristic of HPs (P < .001).
Limitations:
Retrospective design. Single-center study.
Conclusion:
The shape of lumens and nuclei on endocytoscopy can efficiently differentiate among the different types of serrated polyps. (
Clinical Trial Registration Number:
UMIN Clinical Trials Registry UMIN000007850.).
More Related Videos
03:01Author Spotlight: A Reproductive Hysteroscopy Approach for Complete Endometrial Polyp Removal and Enhanced Endometrial Receptivity
Published on: August 2, 2024
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
Related Concept Videos
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
01:26Endoscopic Procedures V: ERCP
Patient...
01:25Endoscopic Procedures II: Colonoscopy
01:29Endoscopic Procedures I: Esophagogastroduodenoscopy
During an EGD, the endoscope can be used to:
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.