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Viral Tracing of Genetically Defined Neural Circuitry
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[Symptomatic giant Virchow-Robin spaces].

S Gronier1, X Ayrignac, C Lamy

  • 1Service de neurologie, pôle de neurosciences cliniques, CHU de Nice, hôpital Pasteur, 30, voie Romaine, 06002 Nice cedex 1, France.

Revue Neurologique
|October 15, 2013
PubMed
Summary
This summary is machine-generated.

Giant dilatation of perivascular spaces (Virchow-Robin spaces) can cause neurological symptoms like epilepsy. This rare condition, identified via MRI, highlights the need for further research into its causes.

Keywords:
Dilatation des espaces de Virchow-RobinDilatation of Virchow-Robin spacesEspaces périvasculaires de Virchow-RobinImagerie par résonance magnétiqueMagnetic resonance imagingPerivascular Virchow-Robin spaces

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Perivascular spaces, or Virchow-Robin spaces (VRS), are typically incidental findings.
  • Massively enlarged VRS are rare, but some reports link them to neurological symptoms.

Observation:

  • This study presents three cases of symptomatic patients with extremely wide VRS.
  • Brain MRI revealed unusual, asymmetric widening of VRS in the subcortical white matter.

Findings:

  • Patients experienced neurological deficits and epilepsy correlating with MRI findings.
  • Two patients exhibited associated white matter hyperintensities, including gliosis and vascular leukoencephalopathy.

Implications:

  • Symptomatic enlarged VRS are uncommon, and their underlying pathophysiology is not fully understood.
  • These cases suggest a potential link between giant VRS dilatation and neurological dysfunction.