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Updated: May 7, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective
Nico Marr1, Stuart E Turvey, Nathalie Grandvaux
1Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Child & Family Research Institute, Vancouver, BC V5Z 4H4, Canada.
Abstract:
Human respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in young children, immunocompromised adults, and the elderly. The innate immune response plays a pivotal role in host defense against RSV, but whether severe outcomes following RSV infection result from excessive or poor innate immune recognition remains unclear. Recent research suggests a situation in which crosstalk between families of pattern recognition receptors (PRRs) occurs in a cell type-dependent manner. The current challenge to empower novel therapeutic approaches and vaccine development is to confirm the role of the individual receptors in RSV pathogenesis in humans.
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