Reproduction in unadapted and adapted cells at 40 degrees C of herpes simplex virus type 1 and type 2 strains

Differences in the reproduction of infectious virus in unadapted and adapted rabbit lung cells at 40 degrees C were observed among 8 strains of herpes simplex virus (HSV) type 1 and 6 strains of HSV type 2. The adapted cells represented a permissive system for some strains of both types at supraoptimal temperature. Reproduction of HSV type 2 was not demonstrated in unadapted cells at 40 degrees C. Strains of HSV type 1 reproduced to different titres in unadapted cells grown at 40 degrees C.