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Apparent exchange rate imaging in anisotropic systems.

Casper K Sønderby¹, Henrik M Lundell, Lise V Søgaard

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Magnetic Resonance in Medicine

|October 15, 2013

Summary

Tissue anisotropy affects apparent exchange rate (AXR) measurements in biological systems. Considering tissue orientation is crucial for accurate AXR estimation in complex tissues like the brain.

Keywords:

AXR DTI cell exchange membrane

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Area of Science:

Biophysics
Neuroimaging
Diffusion MRI

Background:

Double-wave diffusion experiments probe molecular diffusion over time.
This technique can measure water exchange across cellular membranes.
Apparent exchange rate (AXR) quantifies this exchange.

Purpose of the Study:

To investigate the impact of macroscopic tissue anisotropy on AXR measurements.
To evaluate AXR in multicompartment biological systems.

Main Methods:

Collected AXR data from yeast and perfusion-fixated brain tissue using high angular resolution on a preclinical imaging system.
Expanded AXR analysis for anisotropic systems by computing scalar AXR values along the principal diffusion tensor directions.

Main Results:

Yeast AXR and diffusivity were rotationally invariant.
In fixated brain tissue, AXR measurements were sensitive to the orientation of anisotropic structures.
AXR in white matter was robustly estimated along the first two principal diffusion directions, with increased noise along the third.

Conclusions:

Tissue anisotropy significantly influences AXR estimates in complex biological systems.
Accounting for tissue orientation is essential for accurate AXR measurements in biological tissues.