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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Improved anatomical reproducibility in quantitative lower-limb muscle MRI.

Arne Fischmann1, Jasper M Morrow, Christopher D J Sinclair

  • 1University of Basel Hospital, Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, Basel, Switzerland; University of Basel Childrens Hospital, Basel, Switzerland; MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.

Journal of Magnetic Resonance Imaging : JMRI
|October 15, 2013
PubMed
Summary

For reproducible lower-limb muscle MRI, using scout-image-based slice prescription is superior to surface anatomy methods. Consistent subject positioning is crucial for longitudinal quantitative MRI studies.

Keywords:
magnetic resonance imaging (MRI)musclepatient positioningquantitative MRIrepeatability

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Area of Science:

  • Musculoskeletal Imaging
  • Quantitative MRI
  • Lower Limb Anatomy

Background:

  • Quantitative magnetic resonance imaging (MRI) is vital for assessing lower-limb muscles.
  • Reproducibility in MRI measurements is essential for tracking changes over time, particularly in longitudinal studies.

Purpose of the Study:

  • To evaluate the impact of limb positioning and slice prescription methods on the reproducibility of quantitative MRI for lower-limb muscles.
  • To compare scout-image-based versus surface-anatomy-based slice prescription techniques.
  • To assess the influence of subject positioning on MRI reliability.

Main Methods:

  • Ten healthy subjects underwent 3 Tesla MRI using a 2D turbo spin-echo T1-weighted sequence.
  • Imaging was performed at thigh and calf levels with two distinct limb positions, repeated by a second operator.
  • Regions-of-interest (ROIs) were defined on axial slices at fixed distances from the knee and based on surface anatomy.

Main Results:

  • Test-retest reliability for muscle cross-sectional area and ROI overlap was comparable between limb positioning methods.
  • Altering limb position between scans significantly decreased ROI overlap (P < 0.01).
  • Scout-image-based slice prescription demonstrated narrower limits of agreement and higher intraclass correlation coefficients than surface-anatomy-based methods.

Conclusions:

  • Slice prescription using a fixed distance from the knee joint offers superior reproducibility compared to surface anatomy-based methods for quantitative lower-limb MRI.
  • Consistent subject positioning throughout a longitudinal study is recommended, adapting to specific scanner and coil configurations.