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Early childhood wheezing is associated with lower lung function in cystic fibrosis

Clement L Ren1, Michael W Konstan, Margaret Rosenfeld

  • 1Department of Pediatrics, University of Rochester, Rochester, New York.

Pediatric Pulmonology
|October 15, 2013
PubMed

Insights

Childhood wheezing in cystic fibrosis (CF) is common. Early wheezing is linked to reduced lung function (FEV1) in later childhood, highlighting a key early indicator for CF lung health.

Area of Science:

  • Pediatric Pulmonology
  • Cystic Fibrosis Research
  • Respiratory Health

Background:

  • Wheezing is a common symptom in children with cystic fibrosis (CF).
  • The long-term impact of early childhood wheezing on lung function in CF patients is not fully understood.
  • Identifying early clinical markers for lung function decline in CF is crucial for timely intervention.

Purpose of the Study:

  • To investigate the association between wheezing phenotypes in early childhood and subsequent lung function in children with CF.
  • To determine if different patterns of wheezing (transient, late, persistent) have varying impacts on lung function.
  • To identify early childhood wheezing as a potential predictor of impaired lung development in CF.

Main Methods:

  • Analysis of longitudinal data from the Epidemiologic Study of CF (1994-2005).
  • Classification of children into wheezing phenotypes: no wheezing (NW), transient wheezing (TW), late wheezing (LW), and persistent wheezing (PW).
  • Linear regression modeling to predict forced expiratory volume in 1 second (FEV1) at ages 6 to <8 years based on wheezing phenotype.

Main Results:

  • 61% of the 1302 children in the study experienced wheezing within the first six years of life.
  • Any history of wheezing in early childhood was significantly associated with lower FEV1 at ages 6 to <8 years compared to children with no wheezing.
  • Mean predicted FEV1 values were 104% for NW, 98% for TW, 100% for LW, and 96% for PW, with significant differences noted.

Conclusions:

  • Childhood wheezing is a prevalent condition in children with cystic fibrosis.
  • Early childhood wheezing is associated with diminished lung function (FEV1) in later childhood (ages 6 to <8 years).
  • Wheezing in early life serves as a significant clinical indicator linked to reduced lung function in children with CF.
Abstract

Keywords:
cystic fibrosisepidemiologyinfantsspirometrywheeze

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