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Published on: March 30, 2018
Clinicopathologic features of CD5-positive nodal marginal zone lymphoma
Jesse Manuel Jaso1, C Cameron Yin, Sa A Wang
1The University of Texas MD Anderson Cancer Center, Dept of Hematopathology, Box 72, 1515 Holcombe Blvd, Houston, TX 77030;
Objectives:
To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL).
Methods:
We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL.
Results:
Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months).
Conclusions:
CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.
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