Related Experiment Video
Updated: May 7, 2026
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
[Relation between uric acid and coronary artery calcification:a community-based cross-sectional survey among Beijing
Hui-Li Cao1, Bin LV, Xiong-biao Chen
1Department of Radiology, State Key Laboratory of Cardiovascular Disease,Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Insights
High uric acid levels correlated with increased coronary artery calcification in a Beijing study. However, uric acid was not found to be an independent risk factor for this condition.
Area of Science:
- Cardiovascular Research
- Metabolic Health
- Epidemiology
Context:
- Coronary artery calcification (CAC) is a significant indicator of cardiovascular disease.
- The role of uric acid in cardiovascular health is a subject of ongoing research.
- Understanding risk factors for CAC in diverse populations is crucial for public health.
Purpose:
- To examine the association between uric acid levels and the prevalence and severity of coronary artery calcification.
- To investigate whether uric acid is an independent risk factor for CAC in a natural population in Beijing.
Summary:
- A study of 903 adults in Beijing assessed the relationship between uric acid levels and CAC.
- Results showed a higher prevalence and score of CAC with increasing uric acid levels in univariate analysis.
- Multivariate analysis, however, indicated that uric acid is not an independent risk factor for CAC.
Impact:
- This research contributes to understanding the complex relationship between uric acid and cardiovascular risk.
- Findings suggest that while elevated uric acid may be associated with CAC, other factors likely mediate this relationship.
- Highlights the importance of considering confounding variables in epidemiological studies of cardiovascular risk factors.
Objective:
To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.
Methods:
From April to July 2012, 903 subjects from the natural population(aged 37-76 years for men, aged 42-76 years for women)in Xishan community, Beijing, were selected to accept a survey on the risk factors of cardiovascular. Blood tests and CT coronary artery calcium scans were carried out.
Results:
At the 1 Quartile(1 Q), 2 to 3 Quartile(2-3 Q)and 4 Quartile(4 Q)of uric acid levels, the prevalence rates of coronary artery calcium were 37.2% , 45.5% , 60.6% (P<0.001) and the coronary artery calcium scores were (109.7±333.1)AU, (133.9±356.9)AU, (200.8±459.4) AU (P < 0.001)respectively. Data from the univariate logistic regression analysis showed that with the increase of uric acid, the prevalence rates of coronary artery calcium also increased(OR2-3Q = 1.41, 95% CI:1.02-1.95, P = 0.040; OR4Q = 2.60, 95% CI:1.78-3.80, P < 0.001). However, the relationship between uric acid and coronary artery calcium disappeared when using the multivariate logistic regression analysis(OR2-3Q = 0.92, 95% CI: 0.60-1.43, P = 0.713;OR4Q = 1.38, 95% CI:0.80-2.39, P = 0.247).
Conclusion:
Uric acid did not seem to be an independent risk factor for coronary artery calcium, although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid.
More Related Videos
11:30A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
06:57Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease IV: Preventive Measures