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Endogenous opiates and behavior: 2012.

Richard J Bodnar1

  • 1Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, Flushing, NY 11367, United States.

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|October 16, 2013
PubMed
Summary
This summary is machine-generated.

This review covers 2012 research on the endogenous opioid system, detailing how manipulating opioid peptides and receptors impacts behavior. It explores opioids

Keywords:
5-HTACTHANGATPAchBAM22BDNFBENDBFNABNSTBeta-endorphinC/PCARTCBCCKCGRPCPPCRFCTAPCa(2+)DADADLDAMGODORDPDPEDRGDRNDYNDynorphin, Orphanin FQ/nociceptinERKEndomorphinsEnkEnkephalinsFMRIFSHG-protein-coupled receptor kinasesGABAGHRHGIGRKHIVHPAHPLCICSSK(+)KOKORLCLHLPSLTPLenkM3GM6GMAPKMCHMORMSHMenkN-methyl-d-aspartateNACNBNINENMDANONOSNPYNTINTSNa+OFQ/NORL-1OXYOpiate receptorsPAGPBNPCAPDYNPKAPKCPOFQ/NPOMCPTSDPVNPenkRVMSIASNPSPSTZTHCTMJTNFVMHVPVTAacetylcholineadenosine triphosphateadrenocorticotrophic hormoneangiotensinbed nucleus of the stria terminalisbeta-endorphinbeta-funaltrexaminebovine adrenal medulla 22brain-derived neurotrophic factorcalcitonin gene-related peptidecalciumcannabinoidcaudate/putamencholecystokinincocaine and amphetamine-regulated transcriptconditioned place preferencecorticotropin factord-Ala(2),Nme(4),Gly-ol(5)-enkephalind-Ala(2),d-Leu(5)-enkephalind-Pen(2),d-Pen(5)-enkephalind-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 cyclicdelta opioid receptordopaminedorsal raphe nucleusdorsal root gangliondynorphinenkephalinextracellular regulated signal kinasesfollicle stimulating hormonefunctional magnetic resonance imaginggamma-amino-butyric acidgastrointestinalgrowth hormone releasing hormonehigh-performance liquid chromatographyhuman immunodeficiency virushypothalamus–pituitary–adrenalintracranial self-stimulationkappa opioid receptorknockoutl-3,4-dihydroxyphenylalaninel-DOPAleu-enkephalinleutinizing hormonelipopolysaccharidelocus coeruleuslong-term potentiationmelanin concentrating hormonemelanocyte stimulating hormonemet-enkephalinmitogen-activated protein kinasemorphine-3-glucuronidemorphine-6-glucuronidemu opioid receptornaltrindoleneuropeptide Ynitric oxidenitric oxide synthasenociceptinnor-binaltorphaminenorepinephrinenucleus accumbensnucleus tractus solitariusorphan receptor like receptoroxytocinparabrachial nucleusparaventricular nucleuspatient-controlled analgesiaperiaqueductal graypost-traumatic stress disorderpotassiumpreprodynorphinpreproenkephalinprepronociceptin/orphanin FQpro-opiomelanocortinprotein kinase Aprotein kinase Crostral ventromedial medullaserotoninsingle nucleotide polymorphismsodiumstreptozotocinstress-induced analgesiasubstance Ptemporomandibular jointtetrahydrocannibinoltumor necrosis factorvasopressinventral tegmental areaventromedial nucleus of the hypothalamus

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • The endogenous opioid system plays a crucial role in regulating various physiological and behavioral processes.
  • Annual reviews are essential for synthesizing the rapidly advancing research in this complex field.

Purpose of the Study:

  • To summarize research published in 2012 concerning the endogenous opioid system.
  • To detail the behavioral effects of molecular, pharmacological, and genetic manipulations of opioid system components.

Main Methods:

  • Comprehensive literature review of studies published in 2012.
  • Analysis of research investigating opioid peptides, receptors, agonists, and antagonists.
  • Categorization of findings across diverse behavioral and physiological domains.

Main Results:

  • Extensive research in 2012 explored opioid system's influence on behavior through various manipulations.
  • Key areas of investigation included pain, stress, addiction, learning, mood, and neurological disorders.
  • Studies examined molecular, biochemical, and neurophysiological aspects of opioid system function.

Conclusions:

  • The endogenous opioid system remains a critical target for understanding and treating a wide range of conditions.
  • Continued research is vital for elucidating the intricate roles of opioid peptides and receptors in health and disease.