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Endogenous opiates and behavior: 2022.

Richard J Bodnar1

  • 1Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, Flushing, NY 11367, USA.

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|September 13, 2023
PubMed
Summary
This summary is machine-generated.

This review covers 2022 research on the endogenous opioid system, detailing how manipulating opioid peptides and receptors affects behavior, pain, and various physiological functions.

Keywords:
Delta receptorEndorphinEnkephalinFentanylHeroinKappa receptorMorphineMu receptorNociceptinORL-1 receptor

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • The endogenous opioid system plays a crucial role in regulating numerous physiological and behavioral processes.
  • Annual reviews are essential for synthesizing the rapidly evolving research in this complex field.

Purpose of the Study:

  • To provide a comprehensive overview of research published in 2022 concerning the endogenous opioid system.
  • To summarize studies investigating the behavioral effects of manipulating opioid peptides and receptors.
  • To cover a wide range of topics including pain, analgesia, addiction, mood, and physiological functions.

Main Methods:

  • Systematic review and synthesis of scientific literature published in 2022.
  • Categorization of research based on specific topics related to opioid system function.
  • Analysis of studies involving molecular, pharmacological, and genetic manipulation of opioid pathways.

Main Results:

  • Research in 2022 explored the intricate roles of opioid peptides and receptors in diverse functions.
  • Studies examined opioid involvement in pain, analgesia, tolerance, dependence, and drug abuse.
  • The review encompasses effects on mood, neurological disorders, and various organ system functions.

Conclusions:

  • The endogenous opioid system remains a critical target for understanding and treating a wide array of conditions.
  • Continued research is vital for elucidating the complex behavioral and physiological impacts of opioid signaling.
  • This review highlights the broad and significant influence of the opioid system across multiple scientific disciplines.