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[Carcinogenic action of 5-methoxytryptamine related to its transformation into 5-methoxyindolyl-3-acetic acid]
Abstract:
A considerable blastomogenic effect of metabolite serotonin 5-methoxytryptamine (5-MOT) subcutaneously administered for a long time to C57BL/6 mice was established. This effect was decreased noticeably if the further metabolism of 5-MOT into 5-methoxyindolyl-3-acetic acid (5-MIAA) was blocked by pyrazidol. These results explain the fact that the blastomogenic effect of 5-MOT is not direct but is caused by the transformation of 5-MOT into its final carcinogenic metabolite 5-MIAA.
Insights
Long-term administration of the metabolite serotonin 5-methoxytryptamine (5-MOT) caused cancer in mice. Blocking its conversion to 5-methoxyindolyl-3-acetic acid (5-MIAA) reduced this carcinogenic effect, indicating 5-MIAA is the ultimate carcinogen.
Area of Science:
- Biochemistry
- Toxicology
- Oncology