Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.8K
Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

108
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BMI-dependent methylation and clinical signatures in North Indian women with PCOS.

The Indian journal of medical research·2026
Same author

Recombinant Phototagging Enables Fluorescent Labeling of Biomolecules.

Biomacromolecules·2026
Same author

Dynamics of Th17-Associated Cytokine Responses During the Intestinal-Dwelling Protozoan Parasite Giardia duodenalis Infection in Mice and Human Subjects.

Acta parasitologica·2026
Same author

Seroprevalence of Common Viruses in Early Infancy in North Indian Children with Biliary Atresia.

Journal of Indian Association of Pediatric Surgeons·2026
Same author

Maternal choline and prebiotic supplementation ameliorate PCOS traits and reduce intergenerational transmission in rats.

Life sciences·2026
Same author

Pathological and therapeutic implications of Notch overexpression in claudin-low breast cancers.

Human cell·2026

Related Experiment Video

Updated: May 6, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.3K

Common variable immunodeficiency in adults: current diagnostic protocol and laboratory measures.

Yashwant Kumar1, Alka Bhatia

  • 1Department of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Expert Review of Clinical Immunology
|October 17, 2013
PubMed
Summary

Common variable immunodeficiency (CVID) is a frequent immune disorder in adults often diagnosed late due to varied symptoms. This review details CVID

More Related Videos

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

17.7K

Related Experiment Videos

Last Updated: May 6, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.3K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

17.7K

Area of Science:

  • Immunology
  • Genetics

Background:

  • Common variable immunodeficiency (CVID) is a prevalent symptomatic primary immune defect in adults.
  • Delayed diagnosis of CVID is common due to its diverse clinical presentations.
  • Expert knowledge on CVID clinical features, complications, and outcomes has advanced significantly.

Purpose of the Study:

  • To provide a systematic compilation of diagnostic protocols and laboratory measures for CVID.
  • To highlight immunological and molecular defects in adult CVID.
  • To discuss current laboratory criteria and methods for identifying CVID cases.

Main Methods:

  • Review of existing literature on CVID.
  • Compilation of diagnostic criteria and laboratory methods.
  • Discussion of immunological and molecular aspects of CVID.

Main Results:

  • Identified key immunological and molecular defects in adult CVID.
  • Summarized current laboratory criteria and diagnostic methods.
  • Highlighted the variability in CVID presentation affecting diagnosis.

Conclusions:

  • A systematic approach to diagnosis is needed for CVID.
  • Understanding immunological and molecular defects aids in diagnosis.
  • This review offers valuable insights for the multidisciplinary management of CVID.