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Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor

Marta Del Cadia1, Francesca De Rienzo, David A Weston

  • 1Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy.

Bioorganic & Medicinal Chemistry
|October 17, 2013
PubMed

Keywords:
5-HT5-hydroxytryptamine (serotonin)Allosteric binding siteComputational studiesEC(50)FlexStation assaysHEKIC(50)K(d)PalonosetronRadioligand bindingSerotonin receptorSite-directed mutagenesisaffinity constantconcentration of agonist required for half-maximal responseconcentration of antagonist required for half-maximal inhibitionhuman embryonic kidney

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