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Closed loop developments to improve glucose control at home.

Eric Renard1, Claudio Cobelli, Boris P Kovatchev

  • 1Montpellier University Hospital, Department of Endocrinology, Diabetes, Nutrition, INSERM 1001 Clinical Investigation Centre, Institute of Functional Genomics, CNRS UMR 5203, INSERM U661, University of Montpellier 1, Montpellier, France.

Diabetes Research and Clinical Practice
|October 17, 2013
PubMed
Summary
This summary is machine-generated.

Artificial pancreas (AP) systems aim to improve glucose control and reduce the burden for diabetes patients. Recent advancements include smartphone-based platforms for outpatient trials, paving the way for wider use.

Keywords:
Closed loop developmentsGlucose

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Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Diabetes Technology

Background:

  • The development of artificial pancreas (AP) systems has long aimed to achieve near-normal glucose levels for insulin-treated diabetes patients.
  • AP systems seek to reduce the daily burden of insulin dose adjustments for patients managing diabetes.
  • Current AP prototypes utilize portable insulin pumps and continuous glucose monitoring (CGM) sensors.

Purpose of the Study:

  • To assess the technical feasibility, safety, and efficacy of AP systems in home-like conditions.
  • To evaluate patients' ability to manage AP systems in outpatient settings.
  • To explore the potential of wearable, smartphone-based platforms for AP control and remote monitoring.

Main Methods:

  • Utilizing model predictive control algorithms that account for delays in subcutaneous (SC) insulin infusion and glucose sensing.
  • Conducting pilot trials in home-like environments to test AP system performance.
  • Integrating wireless connectivity between insulin pumps, CGM devices, and smartphone-based control platforms.

Main Results:

  • Model predictive control algorithms have demonstrated improved glucose control in hospital settings.
  • Pilot trials in home-like conditions are underway to assess real-world AP system performance.
  • Wearable smartphone-based platforms enable wireless AP control, patient interaction, and remote monitoring.

Conclusions:

  • AP systems hold the potential to revolutionize diabetes treatment by providing safer glucose levels and reducing patient burden.
  • Advancements in wearable technology and control algorithms are expanding AP capabilities to outpatient settings.
  • Further home trials are expected to support the approval and wider adoption of AP systems, improving daily life for diabetes patients.