Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

28
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
28
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

34
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
34
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

37
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
37
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.6K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upper Extremity Deep Vein Thrombosis in Cancer Patients: Clinical Course by Cancer Site.

JACC. CardioOncology·2026
Same author

Peripartum Vascular Calamities: Placental Abruption and Amniotic Fluid Emboli.

Seminars in thrombosis and hemostasis·2026
Same author

Outcomes and predictors of complications after distal deep vein thrombosis: a prospective analysis of 8488 patients.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Glomerular Injury Findings in Patients with Thalassemia Minor.

International journal of molecular sciences·2026
Same author

Maximizing photon utilization in spectroscopic single-molecule localization microscopy using symmetrically dispersed dual-wedge prisms.

Npj imaging·2026
Same author

Platelet and Fibrinogen Dynamics After CAR-T Cell Therapy in Relapsed/Refractory B-Cell Lymphoma May Predict ICANS Onset.

European journal of haematology·2026

Related Experiment Video

Updated: May 6, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

11.6K

Hypercoagulability, parkinsonism, and Gaucher disease.

Hanna Rosenbaum1, Judith Aharon-Peretz, Benjamin Brenner

  • 1Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.

Seminars in Thrombosis and Hemostasis
|October 17, 2013
PubMed
Summary

Gaucher disease (GD), a lysosomal disorder, involves organ damage and coagulation issues. GD mutations are linked to Parkinson disease (PD) risk, suggesting inflammation and coagulation roles in the neurovascular unit.

More Related Videos

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

16.3K
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

19.1K

Related Experiment Videos

Last Updated: May 6, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

11.6K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

16.3K
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

19.1K

Area of Science:

  • Biochemistry
  • Genetics
  • Neurology

Background:

  • Gaucher disease (GD) is a lysosomal storage disorder due to glucocerebrosidase (GCase) deficiency.
  • Accumulation of glucocerebroside in macrophages (Gaucher cells) causes multiorgan dysfunction, including hepatosplenomegaly, cytopenias, and skeletal complications.
  • Neuronopathic forms of GD involve nervous system damage through inflammation, infarcts, and fibrosis.

Purpose of the Study:

  • To explore the association between Gaucher disease and Parkinson disease.
  • To investigate the potential role of inflammation and coagulation in the neurovascular unit concerning GD and PD.
  • To identify thrombophilic risk factors predicting disease severity in GD patients.

Main Methods:

  • Review of clinical and genetic studies linking GCase activity, GD mutations, and Parkinson disease.
  • Analysis of coagulation abnormalities in GD patients.
  • Examination of neuropathological mechanisms in GD.

Main Results:

  • Reduced GCase activity is associated with increased Parkinson disease risk.
  • Coagulation abnormalities are frequent in GD, though hypercoagulability is not.
  • Thrombophilic risk factors may indicate a more severe GD course.

Conclusions:

  • GCase gene mutations are identified as risk factors for Parkinson disease development.
  • Further research is needed to elucidate the mechanisms linking GD and PD, focusing on neurovascular inflammation and coagulation.
  • Understanding these links may improve GD patient management and PD prevention strategies.