Related Experiment Video
Updated: May 6, 2026

The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation
Published on: July 22, 2019
[Leg pain]
J Machetanz1, L Unger, C Stelzner
1Klinik für Neurologie, Krankenhaus Dresden-Neustadt, Städtisches Klinikum, Akademisches Lehrkrankenhaus der TU Dresden, Industriestr. 40, 01129, Dresden, Deutschland, jochen.machetanz@khdn.de.
Investigating leg pain requires examining all lower leg tissues, including the spine, nerves, muscles, and vasculature. This review details their distinct pain mechanisms, clinical presentations, and diagnostic strategies, excluding orthopedic conditions.
Area of Science:
- Clinical Medicine
- Neurology
- Vascular Medicine
Context:
- Leg pain is a frequent clinical complaint requiring comprehensive evaluation.
- Understanding the diverse origins of leg pain is crucial for accurate diagnosis and treatment.
- This review focuses on non-orthopedic causes of leg pain.
Purpose:
- To systematically review the pathophysiology and clinical manifestations of leg pain arising from various tissues.
- To outline diagnostic approaches and therapeutic strategies for leg pain.
- To provide a consolidated resource for clinicians investigating leg pain.
Summary:
- Covers pain mechanisms in the spine, neural plexus, peripheral nerves, muscles, and vasculature.
- Explains disease entities, pathophysiology, and clinical pictures.
- Details diagnostic pathways and therapeutic interventions, excluding bone and joint diseases.
Impact:
- Enhances understanding of leg pain etiology beyond musculoskeletal origins.
- Aids clinicians in diagnosing and managing complex leg pain cases.
- Improves patient outcomes by facilitating targeted treatment strategies.
Related Concept Videos
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Varicose Veins I: Introduction
Muscles that Move the Leg
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Assessing Blood pressure in the Leg
Preparation:
Arteries of Lower Limbs

