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Ceftriaxone-induced hemolysis.

Vivek S Guleria1, Nitin Sharma, Sagar Amitabh

  • 1Department of Internal Medicine, Armed Forces Medical College, Pune - 411 040, India.

Indian Journal of Pharmacology
|October 17, 2013
PubMed
Summary
This summary is machine-generated.

Severe hemolysis is a rare but serious side effect of the common antibiotic ceftriaxone. Prompt drug discontinuation and transfusion led to recovery in a patient with community-acquired pneumonia.

Keywords:
ADRsceftriaxonehemolysis

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Area of Science:

  • Pharmacology
  • Hematology
  • Infectious Diseases

Background:

  • Ceftriaxone is a widely prescribed third-generation cephalosporin antibiotic.
  • Immune hemolytic anemia is a recognized, albeit rare, adverse drug reaction.

Observation:

  • A 60-year-old female patient with community-acquired pneumonia received ceftriaxone.
  • Following the initial dose, she rapidly developed severe hemolytic anemia.

Findings:

  • Hemoglobin levels decreased significantly from 9.6 g/dL to 5.5 g/dL.
  • The patient's condition improved after ceasing ceftriaxone and receiving a blood transfusion.

Implications:

  • This case highlights the potential for life-threatening hemolysis with ceftriaxone use.
  • Clinicians should maintain awareness of this rare adverse effect, even with common antibiotics.