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No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis
Mei-Ling Zhu1, MengYun Wang, Ting-Yan Shi
1Department of Oncology, Xin Hua Hospital affiliated To Shanghai Jiaotong University School of Medicine, Shanghai, China.
Plos One
|October 17, 2013
Summary
This meta-analysis found no significant link between TGFB1 gene variations and the risk of late radiation injury. Further large-scale studies are needed to confirm these findings on radiotherapy toxicity.
Area of Science:
- Genetics and Radiation Oncology
- Molecular Biology and Cancer Research
Background:
- Transforming growth factor-beta 1 (TGF-β1) plays roles in DNA damage response, including fibrosis and apoptosis.
- Previous studies on TGFB1 single nucleotide polymorphisms (SNPs) and radiation injury risk are inconclusive.
Purpose of the Study:
- To conduct a meta-analysis on the association between common TGFB1 SNPs and late radiation-induced normal tissue injury.
- To clarify the controversial findings regarding TGFB1 gene variants and radiotherapy toxicity.
Main Methods:
- Searched MEDLINE, EMBASE, and EBSCO for eligible studies.
- Performed a meta-analysis on three TGFB1 SNPs (rs1800469, rs1800470, rs1800471).
- Included 28 case-only studies from 16 publications.
Main Results:
- No statistical evidence of a significant association between TGFB1 SNPs and overall risk of late radiation-induced normal tissue injury was found.
- Stratified analyses by cancer type, endpoint, ethnicity, and sample size also showed no significant associations.
Conclusions:
- This meta-analysis did not find statistical evidence linking TGFB1 SNPs to the risk of late radiation-induced normal tissue injury.
- Larger, single studies are recommended for further confirmation of these results.
