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Updated: May 6, 2026
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Antinuclear antibody test
Michael O'Sullivan1, Andrew McLean-Tooke, Richard K S Loh
1MBBS, FRACP, FRCPA, is a Consultant Immunologist, Fremantle Hospital and Princess Margaret Hospital for Children, Western Australia.
Abstract:
The antinuclear antibody (ANA) test is widely used as a serological marker of autoimmune disease. Antinuclear antibodies are immunoglobulins or antibodies that bind to one or more antigens expressed within the nucleus of human cells. Used selectively, the ANA test can be a useful laboratory tool to help confirm or exclude the diagnosis of systemic rheumatic disease. However, the relatively high prevalence of ANAs in other inflammatory conditions, as well as healthy individuals, can make a positive result difficult to interpret.
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