Experimental substantiation of the efficiency of antioxidant therapy for post-traumatic arthritis

Experimental post-traumatic arthritis was accompanied by overexpression of pro-inflammatory cytokines and imbalance in the collagen metabolism. Intraarticular injection of mexidol prevented free-radical degradation of collagen structures, contributed to activation of collagen synthesis and cartilage repair, and reduced the severity of inflammatory changes in the joint and the degree of secondary alteration of tissue structures.