Related Experiment Video

Updated: May 6, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
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A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

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Cerebrospinal fluid penetration of tigecycline

Carlo Pallotto1, Maurizio Fiorio, Antonio D'Avolio

  • 1From the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, "Santa Maria della Misericordia" Hospital , Perugia.

Scandinavian Journal of Infectious Diseases
|October 18, 2013
PubMed

Insights

Tigecycline shows poor penetration into cerebrospinal fluid (CSF) for patients with shunt infections. The CSF-to-serum concentration and area under the curve ratios were notably low.

Area of Science:

  • Pharmacokinetics
  • Infectious Diseases
  • Neurosurgery

Background:

  • Ventriculo-atrial shunt infections require effective antibiotic treatment.
  • Tigecycline is a broad-spectrum antibiotic with limited data on central nervous system penetration.

Observation:

  • This case study monitored tigecycline levels in blood and CSF.
  • Patient had a ventriculo-atrial shunt infection.

Findings:

  • Tigecycline demonstrated weak penetration into the cerebrospinal fluid (CSF).
  • The CSF-to-serum concentration ratio was 0.079.
  • The CSF-to-serum area under the concentration-time curve (AUC(0-12)) ratio was 0.067.

Implications:

  • Limited CSF penetration may impact tigecycline efficacy for shunt infections.
  • Further research is needed to evaluate tigecycline's role in CNS infections.
  • Consideration of alternative antibiotics may be necessary for CSF infections.

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