Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

3.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.4K
Pain01:20

Pain

2.1K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropsychological, biological, and electrophysiological outcomes of gamma-tACS in MCI-AD: A case series.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Phase-synchronized iTBS and tACS at 40 Hz gamma frequency: The impact on working memory performance and functional connectivity.

Brain stimulation·2026
Same author

Glutamatergic modulation of transcranial direct current stimulation over the premotor cortex combined with peripheral nerve stimulation promotes observation-execution-related cortical excitability and motor performance.

The Journal of physiology·2026
Same author

The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study.

Translational psychiatry·2026
Same author

Global prevalence and disability burden of brain disorders: Impact of neurological, mental, and substance use disorders.

Neuroscience and biobehavioral reviews·2026
Same author

Beyond composite scores in chronotype assessment: item-level predictive patterns in the Morningness-Eveningness Questionnaire.

Scientific reports·2026
Same journal

Vowel acoustic parameters in speech assessment and rehabilitation of minimally verbal and speech-motor-impaired autistic children: a narrative review.

Frontiers in human neuroscience·2026
Same journal

Toward clinical translation of TMS-EEG: an integrative review of multidimensional neurophysiological measures.

Frontiers in human neuroscience·2026
Same journal

The causal efficacy of consciousness: a neuroscientific analysis and explanation.

Frontiers in human neuroscience·2026
Same journal

Temporal-oscillatory entrainment: a multi-timescale framework for rhythmic coordination from neural to social frequencies.

Frontiers in human neuroscience·2026
Same journal

Role of AQP4 in ameliorating heat stress-induced cellular injury in a cell line model through active heat acclimation.

Frontiers in human neuroscience·2026
Same journal

Correction: Cognitive state monitoring for neuroadaptive information visualization.

Frontiers in human neuroscience·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

268.9K

Putative physiological mechanisms underlying tDCS analgesic effects.

Helena Knotkova1, Michael A Nitsche, Ricardo A Cruciani

  • 11Department of Pain Medicine and Palliative Care, Institute for Non-Invasive Brain Stimulation, Research Division, Beth Israel Medical Center New York, NY, USA ; 2Department of Neurology, Albert Einstein College of Medicine Bronx, NY, USA.

Frontiers in Human Neuroscience
|October 18, 2013
PubMed
Summary
This summary is machine-generated.

Transcranial direct current stimulation (tDCS) shows promise for pain relief by modulating brain activity. This non-invasive technique may alter pain processing networks through specific stimulation targets and electrode placements.

Keywords:
analgesiamechanismsneuromodulationpaintranscranial direct current stimulation (tDCS)

More Related Videos

Author Spotlight: Exploring the Initiation Mechanism of 'Three-Method and Three-Acupoint' Tuina Analgesia in Rats with Nerve Injury
05:24

Author Spotlight: Exploring the Initiation Mechanism of 'Three-Method and Three-Acupoint' Tuina Analgesia in Rats with Nerve Injury

Published on: January 26, 2024

1.2K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

19.8K

Related Experiment Videos

Last Updated: May 6, 2026

Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

268.9K
Author Spotlight: Exploring the Initiation Mechanism of 'Three-Method and Three-Acupoint' Tuina Analgesia in Rats with Nerve Injury
05:24

Author Spotlight: Exploring the Initiation Mechanism of 'Three-Method and Three-Acupoint' Tuina Analgesia in Rats with Nerve Injury

Published on: January 26, 2024

1.2K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

19.8K

Area of Science:

  • Neuroscience
  • Neuromodulation
  • Pain Management

Background:

  • Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method.
  • tDCS influences neuronal excitability and activity in both targeted and remote brain regions.
  • tDCS has demonstrated potential for pain relief in various pain conditions.

Purpose of the Study:

  • To explore the potential physiological mechanisms underlying tDCS-induced analgesia.
  • To hypothesize how specific tDCS montages and targets modulate pain processing networks.
  • To advance understanding of tDCS as a therapeutic tool for pain syndromes.

Main Methods:

  • Review and synthesis of existing research on tDCS and pain.
  • Development of hypotheses regarding the neurophysiological effects of tDCS on pain pathways.
  • Analysis of how different tDCS electrode placements (montages) may influence pain perception.

Main Results:

  • tDCS can induce analgesic effects beyond the directly stimulated areas.
  • Specific tDCS montages are associated with pain relief in experimental and clinical settings.
  • tDCS modulates activity in interconnected cortical and subcortical pain processing networks.

Conclusions:

  • tDCS offers a promising non-invasive approach for pain management.
  • Understanding the precise mechanisms of tDCS in pain modulation is crucial for optimizing treatment.
  • Further research into tDCS-specific targets and montages can enhance its efficacy for various pain syndromes.