Related Experiment Video
Updated: May 6, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Cluster headache associated with acute maxillary sinusitis.
1Department of Neurology, Faculty of Medicine, Skane University Hospital, Lund, S-221 85 Sweden.
Acute maxillary sinusitis can mimic cluster headache, a primary headache disorder. Prompt neuroimaging, including sinuses, is crucial for diagnosing secondary causes, even with a normal neurological exam, to ensure appropriate treatment.
Area of Science:
- Neurology
- Otolaryngology
Background:
- Cluster headache is typically a primary headache disorder without identifiable structural pathology.
- Symptomatic cases of cluster headache have been linked to underlying conditions like tumors, malformations, and infections.
- The diagnostic evaluation of cluster headache remains a challenge.
Purpose of the Study:
- To investigate a case where cluster headache symptoms were potentially triggered by acute maxillary sinusitis.
- To highlight the importance of considering secondary causes in cluster headache presentations.
Main Methods:
- A case study of a 24-year-old male presenting with symptoms consistent with cluster headache.
- Diagnostic workup included a low-dose computed tomography scan.
- Treatment involved antibiotics and sinus puncture for the identified sinusitis.
Main Results:
- The patient's cluster headache attacks resolved completely after treatment for acute maxillary sinusitis.
- The resolution of headache post-sinus treatment suggests a causal or triggering relationship.
- Response to typical cluster headache medications does not rule out a secondary etiology.
Conclusions:
- Neuroimaging, including sinus evaluation, is recommended for patients with cluster headache, even with a normal neurological examination.
- Acute maxillary sinusitis can present with symptoms indistinguishable from cluster headache, necessitating thorough investigation.
Related Concept Videos
Increased Intracranial Pressure l: Introduction
Brain Abscess l: Introduction
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Increased Intracranial Pressure ll: Pathophysiology
Bacterial Meningitis I: Introduction
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.

