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Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report.
1Department of Clinical Sciences, Lund University, Lund S-221 85, Sweden. Bengt.Edvardsson@med.lu.se.
Journal of Medical Case Reports
|December 21, 2014
Summary
A rare case of cluster headache was linked to a non-functioning pituitary adenoma. Imaging is crucial for diagnosing cluster headache, as pituitary tumors can mimic its symptoms.
Area of Science:
- Neurology
- Neuro-oncology
Background:
- Cluster headache is a primary headache disorder within the trigeminal autonomic cephalalgias.
- Secondary causes, including tumors, can mimic cluster headache symptoms.
- The diagnostic criteria for neuroimaging in cluster headache remain debated.
Observation:
- A 49-year-old man presented with unilateral orbital pain consistent with cluster headache.
- Magnetic resonance imaging revealed a pituitary adenoma.
- Hormonal screening confirmed a clinically non-functioning pituitary adenoma.
Findings:
- The patient's cluster headache attacks resolved completely after surgical removal of the pituitary adenoma.
- This case highlights a previously undescribed association between cluster headache and non-functioning pituitary adenoma.
Implications:
- Pituitary adenomas can present as cluster headache, necessitating thorough investigation.
- Contrast-enhanced MRI of the sella turcica is recommended for all patients diagnosed with cluster headache.
- Early diagnosis and treatment of secondary causes are vital for effective management of cluster headache.

