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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Fibroblast growth factor receptor 2: a therapeutic target in gastric cancer

Liu Hong1, Yu Han, Jinqiang Liu

  • 1State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.

Expert Review of Gastroenterology & Hepatology
|October 19, 2013
PubMed

Insights

Gastric cancer is a major global health issue. This review focuses on Fibroblast Growth Factor Receptor 2 (FGFR2) in diffuse gastric cancer, evaluating its role and therapeutic potential with inhibitors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastric cancer is a significant cause of cancer mortality worldwide.
  • Diffuse-type gastric cancer frequently exhibits Fibroblast Growth Factor Receptor 2 (FGFR2) amplification and overexpression.

Purpose of the Study:

  • To review the expression and function of FGFR2 in gastric cancer.
  • To analyze the therapeutic potential of FGFR2 inhibitors for gastric cancer treatment.

Main Methods:

  • Literature review of studies on FGFR2 in gastric cancer.
  • Analysis of FGFR2 expression patterns and functional roles.
  • Evaluation of FGFR2-targeted therapies and their limitations.

Main Results:

  • FGFR2 is a key player in diffuse gastric cancer pathogenesis.
  • FGFR2 inhibitors show promise but face therapeutic challenges.
  • Understanding FGFR2 biology is crucial for treatment development.

Conclusions:

  • FGFR2 is a relevant target for gastric cancer therapy.
  • Further research is needed to overcome limitations of FGFR2 inhibitors.
  • Future developments aim to enhance clinical applications of FGFR2-based treatments.

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