Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

Role of Skin in Vitamin D Synthesis

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...

Drug Toxicity: Dose-Dependent Reactions

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Vitamins

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Implementing simple algorithms to improve glucose and lipid management in people with diabetes and acute coronary syndrome.

Diabetic medicine : a journal of the British Diabetic Association·2019

Same author

Patients with type 1 diabetes in a tertiary setting do not attain recommended lipid targets.

Diabetes & metabolism·2019

Same author

Prenatal ultrasound detection of micrognathia and its association with Robin sequence.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2017

Same author

Better to matter than merely count.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2016

Same author

Common dental features and craniofacial development of three siblings with Ter Haar syndrome.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2013

Same author

Palate lengthening by buccinator myomucosal flaps for velopharyngeal insufficiency.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2012

Same journal

The paradox of peer review: protecting science or policing thought?

Internal medicine journal·2026

Same journal

Immune-related pancytopenia in pregnancy.

Internal medicine journal·2026

Same journal

Crossover effect: causal machine learning reveals opposing mortality responses to mean arterial pressure targets among phenotypically distinct hypertensive patients with septic shock.

Internal medicine journal·2026

Same journal

Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral-treated human immunodeficiency virus infection.

Internal medicine journal·2026

Same journal

Approach to thyroid disorders associated with immune checkpoint inhibitors and tyrosine kinase inhibitors.

Internal medicine journal·2026

Same journal

A scoping review of specialist hypertension clinics.

Internal medicine journal·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Prolonged vitamin D intoxication: presentation, pathogenesis and progress.

D A Bell¹, M J Crooke, N Hay

¹Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine WA, Royal Perth Hospital, Perth, Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.

Internal Medicine Journal

|October 19, 2013

Summary

This summary is machine-generated.

Vitamin D toxicity from unactivated vitamin D (calciferol) therapy is rare but may increase with high-dose preparations. This toxicity can cause reversible hypercalcaemia and kidney issues, with parathyroid hormone levels potentially remaining high.

Keywords:

acute renal injury hypercalcaemia vitamin D intoxication

More Related Videos

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Related Experiment Videos

Last Updated: May 6, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Area of Science:

Endocrinology
Nephrology
Clinical Pharmacology

Background:

Unactivated vitamin D (calciferol) therapy is used for vitamin D deficiency.
High-dose preparations of unactivated vitamin D are becoming more accessible.
Vitamin D toxicity is a potential adverse effect of excessive supplementation.

Observation:

Vitamin D toxicity from unactivated vitamin D (calciferol) is a rare cause of hypercalcaemia.
The incidence of this toxicity may rise with increased availability of high-dose unactivated vitamin D.
Prolonged toxicity can lead to hypercalcaemia and renal impairment.

Findings:

Hypercalcaemia associated with vitamin D toxicity is often reversible.
Renal impairment resulting from vitamin D toxicity may be partially reversible.
Parathyroid hormone levels might not be suppressed in cases of unactivated vitamin D toxicity, particularly with coexisting renal disease.

Implications:

Clinicians should be aware of the potential for increased vitamin D toxicity with new high-dose formulations.
Monitoring calcium and renal function is crucial in patients receiving high-dose unactivated vitamin D.
The atypical suppression of parathyroid hormone in vitamin D toxicity warrants further investigation, especially in patients with kidney compromise.