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Multiple sclerosis treatment and infectious issues: update 2013

A Winkelmann1, M Loebermann, E C Reisinger

  • 1Department of Neurology, University of Rostock, Rostock, Germany.

Clinical and Experimental Immunology
|October 19, 2013
PubMed

Insights

Immunomodulation and immunosuppression in multiple sclerosis (MS) increase infection risk. This review updates infectious disease risks and prevention strategies for current and emerging MS therapies.

Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Immunomodulatory and immunosuppressive therapies are crucial for managing multiple sclerosis (MS).
  • These treatments can increase the risk of serious infections.
  • Understanding these risks is vital for patient safety.

Purpose of the Study:

  • To review current data on infections associated with multiple sclerosis treatments.
  • To highlight prevention strategies for infectious diseases in MS patients.
  • To update awareness of infectious risks for both new and established MS therapies.

Main Methods:

  • Comprehensive literature review of recent studies on MS treatments and infections.
  • Analysis of data on specific infections linked to disease-modifying therapies (DMTs).
  • Evaluation of current warning notices and surveillance recommendations.

Main Results:

  • Certain disease-modifying therapies (DMTs) for MS are associated with specific severe infections.
  • Long-term monitoring and multi-disciplinary surveillance are necessary for at-risk patients.
  • Updated information on infectious complications is crucial for managing MS patients.

Conclusions:

  • Effective management of multiple sclerosis requires careful consideration of infection risks.
  • Proactive monitoring and prevention strategies are essential for patients on immunomodulatory/immunosuppressive therapies.
  • Continuous updates on infectious issues are needed for safe and effective MS treatment.
Keywords:
disease-modifying treatmentimmunosuppressioninfectionmultiple sclerosisside effects

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