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Avermectin induced inflammation damage in king pigeon brain
Li-Jie Chen1, Bao-Hong Sun, Jian Ping Qu
1Department of Veterinary Physiology, Northeast Agricultural University, Harbin 150030, PR China; Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China.
Chemosphere
|October 19, 2013
Summary
Avermectin (AVM) exposure causes significant inflammation and brain damage in king pigeons, affecting histological structures and targeting mitochondria. This study highlights AVM
Area of Science:
- Veterinary Neurology
- Toxicology
- Cellular Biology
Background:
- Avermectin (AVM) is widely used in veterinary medicine.
- Understanding AVM's neurotoxic effects is crucial for animal health.
- Limited data exists on AVM's impact on avian brain inflammation.
Purpose of the Study:
- To investigate the neuroinflammatory effects of Avermectin (AVM) in the brains of American king pigeons.
- To assess AVM-induced histological and ultra-structural damage in avian neural tissues.
- To identify potential cellular targets of AVM toxicity in the nervous system.
Main Methods:
- Eight-week-old American king pigeons were administered diets supplemented with AVM (20, 40, or 60 mg/kg) for 30, 60, or 90 days.
- Expression levels of inflammatory factors (iNOS, PTGEs, NF-κB) were measured.
- Histological and ultra-structural examinations of brain tissues (cerebrum, cerebellum, optic lobe) were performed.
Main Results:
- AVM administration significantly increased the expression of iNOS, PTGEs, and NF-κB in pigeon brains (P<0.05).
- Disorganized histological and ultra-structural changes were observed in the cerebrum, cerebellum, and optic lobe.
- Inflammatory and histopathological damage were evident, with mitochondria identified as a primary targeted organelle.
Conclusions:
- Avermectin induces significant neuroinflammation and structural damage in king pigeon brains.
- Mitochondria appear to be a key target organelle in AVM-induced neuroinflammation.
- This study provides novel insights into the toxicological effects of AVM on avian neurological systems.
