Cancer-associated osteoclast differentiation takes a good look in the miR(NA)ror
David L Waning1, Khalid S Mohammad, Theresa A Guise
1Division of Endocrinology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Cancer Cell
|October 19, 2013
Abstract:
Tumor-bone cell interactions are critical for the development of metastasis-related osteolytic bone destruction. In this issue of Cancer Cell, Ell and colleagues show how a discrete miRNA network regulates osteoclastogenesis during breast cancer bone metastasis. A signature of upregulated miRNAs may have diagnostic and therapeutic implications for bone metastases.
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