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Antimutagenic activity of wheat polypeptides in human cells exposed to cadmium chloride
G D Zasukhina1, I M Vasilyeva, I A Kadnikov
1N. I. Vavilov Institute of General Genetics, the Russian Academy of Sciences, Moscow, Russia. Zasukhina@vigg.ru.
Abstract:
Antimutagenic effects of polypeptides isolated from Triticum kiharae wheat plantule extracts have been studied on human cells exposed to cadmium chloride. The most effective polypeptide Tk-AMP-BP β -purothionin exhibited higher antimutagenic activity than wheat water extract and another peptide isolated from the same wheat species, Tk-AMP-γ 2 defensin; it also produced a pronounced antioxidant effect. This polypeptide can be used as a preventive agent for reducing the mutagenic potential of some environmental pollutants and for correction of human diseases associated with the defense system defects.
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