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Prospects of therapy for infections with human T-lymphotropic virus type III

M S Hirsch, J C Kaplan

    Annals of Internal Medicine
    |November 1, 1985
    PubMed

    Insights

    Researchers are exploring antiviral drugs like suramin and interferon alpha to combat Human T-lymphotropic virus type III (HTLV-III) replication. Combination therapies may be key for treating acquired immunodeficiency syndrome.

    Area of Science:

    • Virology
    • Immunology
    • Pharmacology

    Background:

    • Human T-lymphotropic virus type III (HTLV-III) is a significant pathogen.
    • The virus has multiple targets within its replicative cycle.

    Purpose of the Study:

    • To review current antiviral agents and therapeutic strategies for HTLV-III.
    • To highlight the need for controlled clinical trials in managing HTLV-III infection and acquired immunodeficiency syndrome (AIDS).

    Main Methods:

    • Review of in-vitro studies and early clinical trials of antiviral agents.
    • Discussion of ongoing double-blind, placebo-controlled trials for interferon alpha.
    • Emphasis on the necessity of multicenter collaborative trials.

    Main Results:

    • Several inhibitors of reverse transcriptase, including suramin, HPA-23, and trisodium phosphonoformate, show in-vitro activity.
    • Recombinant interferon alpha-A, ribavirin, and ansamycin are identified as significant antiviral agents.
    • Interferon alpha demonstrates efficacy in inhibiting viral replication at achievable serum levels.

    Conclusions:

    • Optimal therapeutic regimens for HTLV-III require carefully controlled, multicenter trials.
    • Prolonged combination therapy with antiviral and immunomodulating agents may be necessary for effective HTLV-III replication control and AIDS treatment.
    Keywords:
    Acquired Immunodeficiency Syndrome--prevention and controlDiseasesDrugsHiv InfectionsTreatmentViral Diseases

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