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Steroid binding protein(s) in yeasts.

M Das, A Datta

    Biochemistry International
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    A specific progesterone binding protein was found in both Candida albicans and Saccharomyces cerevisiae yeast cells. This protein showed significantly higher activity in the pathogenic Candida albicans compared to Saccharomyces cerevisiae.

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    Area of Science:

    • Biochemistry
    • Mycology
    • Molecular Biology

    Background:

    • Progesterone binding proteins play crucial roles in cellular processes.
    • Yeasts like Candida albicans and Saccharomyces cerevisiae are important model organisms in biological research.
    • Understanding specific protein activities can reveal differences between pathogenic and non-pathogenic species.

    Purpose of the Study:

    • To detect and characterize progesterone binding proteins in Candida albicans and Saccharomyces cerevisiae.
    • To compare the specific activity of these proteins between the two yeast species.

    Main Methods:

    • Cytosol preparation from glucose-grown yeast cells.
    • Detection and quantification of progesterone binding protein activity.

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    Main Results:

    • A progesterone binding protein was identified in the cytosol of both Candida albicans and Saccharomyces cerevisiae.
    • The specific activity of this binding protein was markedly higher in Candida albicans than in Saccharomyces cerevisiae.

    Conclusions:

    • Candida albicans possesses a progesterone binding protein with significantly higher specific activity compared to Saccharomyces cerevisiae.
    • This finding may contribute to understanding the biological differences between these two yeast species.