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Olive baboons: a non-human primate model for testing dengue virus type 2 replication.

Iris Valdés1, Lázaro Gil, Jorge Castro

  • 1Center for Genetic Engineering and Biotechnology (CIGB), Avenue 31, PO Box 6162, Havana 6, 10 600, Cuba.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|October 22, 2013
PubMed
Summary

Olive baboons (Papio anubis) effectively model dengue virus type 2 (DENV-2) infection, showing viremia and antibody responses. Researchers recommend using baboons with the lowest DENV-2 dose for vaccine development.

Keywords:
African green monkeysBaboonsDengueNon-human primatesVaccineViremia

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Area of Science:

  • Virology
  • Primate Models
  • Infectious Diseases

Background:

  • Olive baboons (Papio anubis) share genetic and physiological similarities with humans.
  • Baboons are frequently utilized in evaluating new vaccine formulations.

Purpose of the Study:

  • To assess the suitability of olive baboons as a non-human primate model for dengue virus type 2 (DENV-2) infection.
  • To compare DENV-2 infection dynamics in baboons versus African green monkeys.

Main Methods:

  • Two doses of DENV-2 (10^3 and 10^4 pfu) were administered to olive baboons.
  • African green monkeys served as positive controls, receiving the same DENV-2 doses.

Main Results:

  • High levels of viremia were observed in both baboons and African green monkeys.
  • A trend towards more days of viremia and consistent viral titers was noted with the lower DENV-2 dose (10^3 pfu).
  • Baboons showed positive virus isolation approximately one day later than African green monkeys, with all infected animals developing antiviral and neutralizing antibodies.

Conclusions:

  • Olive baboons represent a viable non-human primate model for experimental DENV-2 infection.
  • The study recommends utilizing baboons for future DENV-2 vaccine testing, specifically with the lower dose of 10^3 pfu.