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Progress in translational research on intracerebral hemorrhage: is there an end in sight?

Guohua Xi1, Jennifer Strahle1, Ya Hua1

  • 1Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States.

Progress in Neurobiology
|October 22, 2013
PubMed

Insights

Intracerebral hemorrhage (ICH) is a deadly stroke subtype lacking specific treatments. This review highlights translational research progress and ongoing clinical trials for ICH, offering hope for new therapies.

Area of Science:

  • Neurology
  • Translational Medicine
  • Stroke Research

Background:

  • Intracerebral hemorrhage (ICH) is a significant cause of stroke-related mortality and disability.
  • Current therapeutic options for ICH are limited, necessitating advancements in understanding and treatment.
  • Translational research is crucial for bridging basic science discoveries to clinical applications in ICH.

Purpose of the Study:

  • To review the progress of translational studies investigating intracerebral hemorrhage (ICH).
  • To cover the etiology, natural history, and impact of ICH on various physiological systems.
  • To discuss current and future clinical trials for ICH management.

Main Methods:

  • Literature review of experimental and translational studies on ICH.
  • Analysis of research on ICH animal models and their relevance.
  • Examination of studies on the immunological and cardiovascular effects of ICH.
  • Synthesis of information on ongoing and proposed clinical trials for ICH.

Main Results:

  • Significant progress has been made in understanding ICH pathophysiology through translational research.
  • Animal models provide valuable insights into ICH mechanisms and potential therapeutic targets.
  • ICH impacts immune and cardiac systems, offering avenues for novel treatment strategies.
  • Several clinical trials are underway or planned to evaluate new ICH interventions.

Conclusions:

  • Translational research is vital for developing effective therapies for intracerebral hemorrhage.
  • Further investigation into ICH's systemic effects and refined clinical trial designs are needed.
  • Advancements in understanding and treatment hold promise for improving outcomes in ICH patients.

Keywords:
Animal modelsBrain edemaIntracerebral hemorrhageIron

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