Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

4.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.7K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

75
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
75
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

866
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
866
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

32
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
32
Pneumonia IV: Management01:28

Pneumonia IV: Management

1.2K
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
1.2K
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

49
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
49

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Where Did this Come From: Lumbar Puncture for All Infants with Suspected Tuberculosis Disease?

Journal of the Pediatric Infectious Diseases Society·2026
Same author

I Zinc, Therefore I Am: Context is Key.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

The Duration Dilemma: With and Without Definitive Diagnostics.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same author

Association of Intended Mode of Delivery With Neonatal and Maternal Outcomes at 22-25 Weeks of Gestation.

O&G open·2026
Same author

Executive Summary: State-of-the-Art Review: Infectious Diarrhea.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

State-of-the-Art Review: Infectious Diarrhea.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same journal

Identification of an early-formed HIV-1 circulating recombinant form (CRF202_BC) in the southern border region of Yunnan, China.

The Journal of infection·2026
Same journal

Streptococcus agalactiae bone and joint infection: a multicentre observational study 2014-23.

The Journal of infection·2026
Same journal

Respiratory viral detection in adult severe acute respiratory infection post-COVID-19 pandemic: implications for antimicrobial stewardship.

The Journal of infection·2026
Same journal

Home-Based Rapid Testing and Early Antiviral Treatment as a Potential Strategy to Blunt Pediatric Influenza Peak.

The Journal of infection·2026
Same journal

Landscape and ecological correlates of tick-associated viruses in Inner Mongolia, China.

The Journal of infection·2026
Same journal

Age-associated impairment of humoral and cellular immune responses to SARS-CoV-2 in a large community cohort with hybrid immunity.

The Journal of infection·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

5.5K

Neonatal sepsis: progress towards improved outcomes.

Andi L Shane1, Barbara J Stoll

  • 1Division of Infectious Disease, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA.

The Journal of Infection
|October 22, 2013
PubMed
Summary
This summary is machine-generated.

Neonatal infections cause over 1.4 million deaths annually. Strategies like antimicrobial stewardship and hygiene are crucial for preventing early- and late-onset sepsis in newborns.

Keywords:
BurdenManagementNeonatal sepsisPrevention

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.8K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

600

Related Experiment Videos

Last Updated: May 6, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

5.5K
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.8K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

600

Area of Science:

  • Neonatalogy
  • Infectious Diseases
  • Public Health

Background:

  • Neonates have immature immune systems, increasing susceptibility to perinatal infections.
  • Neonatal infections contribute to over 1.4 million deaths globally each year.
  • Risk factors for early-onset sepsis (EOS) include prematurity and maternal Group B Streptococcus (GBS) colonization.

Purpose of the Study:

  • To summarize the epidemiology and risk factors of neonatal infections.
  • To highlight emerging pathogens and effective prevention strategies for neonatal sepsis.

Main Methods:

  • Review of existing literature on neonatal infections, risk factors, and prevention.
  • Analysis of data on global burden of neonatal sepsis and mortality.
  • Identification of key interventions for reducing healthcare-associated infections.

Main Results:

  • Early-onset GBS infections have decreased due to intrapartum prophylaxis.
  • Gram-negative pathogens are an emerging cause of early-onset sepsis.
  • Late-onset sepsis (LOS) is often caused by Gram-positive organisms and invasive candidiasis, particularly in premature infants.
  • Prophylactic fluconazole reduces invasive candidiasis in very low birthweight (VLBW) neonates.

Conclusions:

  • Preventing neonatal infections requires addressing both early- and late-onset sepsis.
  • Effective strategies include antimicrobial stewardship, infection control practices, and targeted prophylaxis.
  • Continued surveillance and research are vital for combating neonatal sepsis.