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Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α

Avery L McIntosh1, Anca D Petrescu, Heather A Hostetler

  • 1Department of Physiology and Pharmacology, Texas A&M University, TVMC, College Station, TX 77843-4466, United States.

FEBS Letters
|October 22, 2013
PubMed
Summary

Liver type fatty acid binding protein (L-FABP) interacts with Hepatocyte nuclear factor 4α (HNF4α), influencing its activity. This study reveals L-FABP binds HNF4α, altering its structure and enhancing its function in the nucleus.

Keywords:
ACBPCDFRETFatty acid binding proteinHNF4αHepatocyte nuclear factor 4αL-FABPLCFALCFA-CoALSCMLiverPPARαacyl CoA binding proteincircular dichroismfluorescence resonance energy transferhepatocyte nuclear factor 4αlaser scanning confocal microscopyliver type fatty acid binding proteinlong chain fatty acidlong chain fatty acyl CoAperoxisome proliferator activated receptor-α

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