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The stromal compartments in pancreatic cancer: are there any therapeutic targets?

Serena Lunardi1, Ruth J Muschel1, Thomas B Brunner2

  • 1Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Churchill Hospital, RRI, Oxford OX3 7LJ, UK.

Cancer Letters
|October 22, 2013
PubMed

Keywords:
COX-2CTLsCytotoxic T LymphocytesDCsECMEGFFAKFAP-αFGFHSCsIGF-1Insulin Growth Factor-1MDSCsMMPPCCsPDACPDGFPSCsPancreatic Stellate CellsPancreatic cancerSERBIPINE2SHHSPARCStromaTAMsTGF-βTIMPTregsTumour microenvironmentVEGFcyclooxygenase-2dendritic cellsepidermal growth factorextracellular matrixfibroblast activation protein-αfibroblast growth factorfocal adhesion kinasehepatic stellate cellmatrix metalloproteinasesmyeloid-derived suppressor cellspancreatic cancer cellspancreatic ductal adenocarcinomaplatelet-derived growth factorregulatory T cells (Tregs)secreted protein acidic and rich in cysteineserine protease inhibitor nexin 2sonic hedgehogtPAtissue inhibitors of metalloproteinasestissue plasminogen activatortransforming growth factor-βtumour associated macrophagesuPAurokinase-type plasminogen activatorvascular endothelial growth factorα-SMAα-smooth muscle actin

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