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Updated: May 6, 2026
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
Published on: March 3, 2020
γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery
Sandip V Jadhav1, Sumeet K Singh, Rahi M Reja
1Department of Chemistry, Indian Institute of Science Education and Research, Dr Homi Bhabha Road, Pune 411 008, India. hn.gopi@iiserpune.ac.in.
Abstract:
The stability and compatibility of designed coiled coil peptides towards the selective incorporation of γ(4)-amino acids at the hydrophobic positions of the heptad repeat are studied. Investigations reveal that the low thermal denaturation temperature of γ(4)-residue mutated coiled coils can be utilized as a mild hyperthermia trigger in liposomes.
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