Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: a meta-analysis
Hai-xia Meng1, Mu-ge Qi, Yuan-yuan Yi
1Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical College, Hohhot, 010050, Inner Mongolia Autonomous Region, China.
Purpose:
The association between apolipoprotein E (ApoE) gene polymorphism and the risk of recurrent pregnancy loss (RPL) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship.
Method(S):
We searched the PubMed, Embase, and Web of Science data- bases for studies related to the association between the ApoE genotype and the risk of RPL. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association.
Result(S):
Seven studies, including 2,090 RPL cases and 742 control samples, were identified. The results showed a significant association between ApoE E4 mutation and RPL risk (for E4 allele: OR =1.98, 95 %CI =1.14-3.43, P=0.499; for E2E3 vs. E3E3: OR =1.33, 95%CI =1.12-1.42, P=0.008; for E2E4 vs. E3E3: OR =1.26, 95 % CI =1.07-1.49, P=0.005).
Conclusion(S):
The meta-analysis suggests an association between ApoE E4 mutation and increased risk of RPL.
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