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Inhaled corticosteroids for asthma: on-demand or continuous use.
1Institute of Infection, Immunity & Inflammation, University of Glasgow and Respiratory Medicine, Gartnavel General Hospital, Glasgow, G12 OYN, UK.
Expert Review of Respiratory Medicine
|October 24, 2013
Summary
For mild persistent asthma, on-demand inhaled corticosteroid treatment may be as effective as continuous therapy. This review examines the evidence for using inhaled corticosteroids intermittently versus daily for asthma symptom relief.
Area of Science:
- Pulmonology
- Pharmacology
- Clinical Medicine
Background:
- Continuous inhaled corticosteroid (ICS) therapy is effective for mild persistent asthma.
- Many patients prefer intermittent ICS use due to symptom flares rather than daily adherence.
- This has led to proposals for on-demand ICS treatment for mild persistent asthma.
Purpose of the Study:
- To review the pharmacological properties of ICS used in on-demand treatment trials.
- To evaluate the efficacy and safety of on-demand versus continuous ICS treatment for mild persistent asthma in all age groups.
- To discuss the role of on-demand ICS in asthma management and future strategies.
Main Methods:
- Review of pharmacological data for ICS.
- Analysis of clinical trial evidence comparing on-demand and continuous ICS treatment.
- Discussion of asthma management guidelines and future research directions.
Main Results:
- Continuous ICS treatment is highly effective, but benefits may persist with delayed initiation.
- Evidence for the efficacy and safety of on-demand ICS treatment in mild persistent asthma is reviewed.
- The article explores the place of on-demand ICS within broader asthma management strategies.
Conclusions:
- On-demand ICS treatment is a proposed alternative to continuous therapy for mild persistent asthma.
- The review assesses the evidence base for on-demand ICS efficacy and safety.
- Future management strategies for mild persistent asthma are considered.
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