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Methodology for Sputum Induction and Laboratory Processing
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Sputum ADAM8 expression is increased in severe asthma and COPD

K M Oreo1, P G Gibson, J L Simpson

  • 1Virus Infections/Immunity Vaccines & Asthma, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia; Severe Asthma Network, Woolcock Institute of Medical Research, Glebe, NSW, Australia; The University of Sydney, Camperdown/Darlington, NSW, Australia.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|October 24, 2013
PubMed
Summary

A disintegrin and metalloproteinase domain 8 (ADAM8) is elevated in severe asthma and COPD, correlating with increased neutrophils. This suggests ADAM8 may play a role in neutrophil migration in these respiratory diseases.

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