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Oxidative stress status in patients with melasma
Havva Yıldız Seçkin1, Göknur Kalkan, Yalçın Baş
1Department of Dermatology and.
Cutaneous and Ocular Toxicology
|October 24, 2013
Summary
Oxidative stress is increased in melasma, disrupting the oxidant-antioxidant balance. This finding offers new insights into melasma
Area of Science:
- Dermatology
- Biochemistry
- Oxidative Stress Research
Background:
- Melasma is an acquired skin condition causing facial hyperpigmentation.
- Its pathogenesis remains unclear, and effective treatments are lacking.
- No prior studies investigated the role of oxidative stress in melasma.
Purpose of the Study:
- To evaluate the role of oxidative stress in the pathogenesis of melasma.
Main Methods:
- Compared 50 melasma patients with 50 healthy controls.
- Assessed Melasma Area Severity Index (MASI) for clinical evaluation.
- Measured serum levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde, nitric oxide, and protein carbonyls.
Main Results:
- Significantly higher SOD and GSH-Px enzyme activities in melasma patients (p < 0.001).
- Significantly lower protein carbonyl levels in melasma patients (p < 0.001).
Conclusions:
- Melasma is associated with increased oxidative stress and a disrupted oxidant-antioxidant balance.
- Findings enhance understanding of melasma etiology and pathogenesis.
- Results may inform the development of novel therapeutic strategies.
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