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Updated: May 6, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
[microRNA: new diagnostic and therapeutic tools in liver disease?]
Angélique Gougelet1, Sabine Colnot
1Inserm U1016, Institut Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris, France; CNRS UMR 8104, 75014 Paris, France - université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
Abstract:
microRNA are small non coding RNA, which negatively regulate the expression of their targets. Due to their various targets, miRNAs play a key role in number of physiological processes and in oncogenesis. The identification of specific miRNA signatures in various types of tumours, including hepatocellular carcinoma (HCC), highlights the dual role of miRNA, both oncogenes and tumour suppressors. Here, we review the current knowledge concerning the deregulation of miRNA expression in liver disease. All studies focusing on miRNAs argue for their possible use as diagnostic, prognostic and therapeutic markers. Here, we preferentially discuss the promising therapeutic strategies based on miRNAs that have been tested in HCC.
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