[Clathrin-independent endocytosis: free the way!]

Along the years, the interest paid to the study of endocytosis has never wavered as this process plays such an essential role in many cellular functions. Cell growth, adhesion and differentiation, regulation of signaling induced by membrane receptors or infection by viral particles are all dependent on the entry of molecules into the cell. Once the clathrin-dependent endocytosis well characterized, it has become apparent that other entry pathways also existed in the cell. This review is intended to provide an update on recent advances that establish with certainty the existence of endocytic pathways independent of clathrin and highlight their specific regulators.