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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

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Iron and transfusion medicine

Sophie Waldvogel-Abramovski1, Gérard Waeber, Christoph Gassner

  • 1Service régional vaudois de transfusion sanguine, Epalinges, Switzerland.

Blood Reviews
|October 24, 2013
PubMed

Blood bankers have focused their energy to secure blood transfusion, and only recently have studies been published on the effect of blood donation on iron metabolism. In many facilities, hemoglobin measurement is only performed just before or even during blood donation, but the determination of iron stores is largely ignored. The 2013 paradox of transfusion medicine is due to the fact that blood donation may be harmful and leads to iron deficiency with or without anemia, but for other individuals, it may be a healthy measure preventing type 2 diabetes. The purpose of this review is to discuss iron metabolism in the perspective of blood donation, notably regarding their possible genetic profiles that eventually will discriminate "good" iron absorbers from "bad" iron responders.

Keywords:
GWASHHHbIDWAIronIron deficiency anemiaIron deficiency without anemiaIron metabolismIron overloadNASHSNPT2DTransfusion medicineType 2 diabetesZPPgenome wide association studieshemoglobinhereditary hemochromatosisiron deficiency without anemianonalcoholic fatty liver diseasesTfrsingle nucleotide polymorphismsoluble transferrin receptortype 2 diabeteszinc protoporphyrin

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